Composer/guitarist/rapper/D.J. Gene Pritsker has written over five hundred compositions, including chamber operas, orchestral and chamber works, electro-acoustic music and songs for hip-hop and rock ensembles. All of his compositions employ an eclectic spectrum of styles and are influenced by his studies of various musical cultures.

He is the founder and leader of Sound Liberation; an eclectic hip hop-chamber-jazz-rock-etc. ensemble who have released cd's on Col-legno, Composers Concordance and Innova Records. Gene's music has been performed all over the world at various festivals and by many ensembles and performers, including the Adelaide Symphony, MDR Symphony, The Athens Camarata, China Philharmonic Orchestra, Brooklyn, Shanghai and Berlin Philharmonic, Sinfonietta Riga, Orchester des Pfalztheaters, Yomiuri Nippon Symphony Orchestra, Anhaltische Philharmonie as well as such soloists as Anne Akiko Meyers, Lara St. John, Kathleen Supove, Martin Kuuskmann and Simone Dinnerstein. He has worked closely with Joe Zawinul and has orchestrated major Hollywood movies, Including 'Cloud Atlas', for which he wrote additional music and composed his ''Cloud Atlas Symphony', to be released in 2014/15 on.

The New York Times described him as "...audacious...multitalented." Joseph Pehrson, writing in The Music Connoisseur, described Pritsker as "dissolving the artificial boundaries between high brow, low brow, classical, popular musics and elevates the idea that if it's done well it is great music, regardless of the style or genre". Raul d'Gama Rose writes in All About Jazz: "Barring the obvious exceptions, much of 21st century composition appears to be thinning in significance, but this might be about to change. Gene Pritsker is one of a very spare handful of composers effecting this change." Evan Burke writes in ICareIf YouListen: "Pritsker seems to look at all music as one genre, in which all other possible styles, sounds and traditions are meant to be used as building blocks and palette colors, combined in various configurations to create a boundless whole. This result is almost always more interesting, and representative of how most new music will be born in the 21st century, as genres and barriers begin to vanish, and as styles begin cross-fertilizing in previously unimagined ways." Classical Music Sentinel writes: "His expressive reach is so wide as to encompass everything from ethno/techno, rock/jazz fusion, classical opera and more, and it all seems to be effortlessly integrated within his anima and comes out through different facets of his persona. You could almost see him as a modern day renaissance man.